Spravato® (Esketamine)
Spravato® (Esketamine) Treatment in Eugene, Oregon
An FDA-approved nasal spray for treatment-resistant depression, delivered as part of Lonerock's comprehensive psychiatric care in a calm, monitored clinical setting. Covered by most major Oregon insurers, Spravato® is often the option that finally works after years of trying.
Medically reviewed by Camille Pincock, MS · Last reviewed June 2026
The basics
What Is Spravato®?
Spravato® is an FDA-approved esketamine nasal spray for treatment-resistant depression — and for major depressive disorder with acute suicidal ideation. Unlike IV ketamine, it's FDA-approved, REMS-regulated, covered by most insurers, and self-administered under clinical supervision. It's a regulated, insurance-friendly path to a fast-acting, glutamate-based treatment.
How Spravato® Works
Spravato® acts on the brain's glutamate system rather than serotonin, which is why it can work faster than conventional antidepressants for people with treatment-resistant depression. It's closely related to ketamine therapy but follows an FDA-approved, insurance-covered pathway.
Because every patient responds differently, Spravato® is prescribed only after a comprehensive psychiatric evaluation to determine whether it's the right treatment.
Your treatment journey
What to Expect During Treatment
Your Spravato® journey at Lonerock Clinic begins with a personalized evaluation to confirm eligibility and tailor your care plan. Each session is designed to maximize comfort, safety, and therapeutic benefit.
Comprehensive Psychiatric Evaluation
Before treatment begins, you'll meet with our psychiatric team to review your history, current symptoms, previous medications, and overall health to determine whether Spravato® is the most appropriate treatment.
Pre-Treatment Preparation
Before your appointment, our care team provides detailed instructions and ensures you're medically cleared for treatment.
Supervised Administration
You'll self-administer Spravato® under clinical supervision, then rest comfortably while our team monitors your response.
Post-Treatment Recovery
After the session, we'll discuss your experience, track your progress, and provide next-step guidance to optimize long-term results.
Is Spravato® Right for You?
Spravato® is for adults with treatment-resistant depression — generally those who've tried two or more antidepressants without adequate relief. It requires a full evaluation, which is part of our psychiatric care. We'll help determine whether Spravato®, Ketamine-Assisted Psychotherapy (KAP), medication management, or another evidence-based treatment is the best fit for your needs.
Why Lonerock
Why Receive Spravato® at Lonerock?
- Comprehensive psychiatric evaluations before treatment
- Medication management under the same care team
- Experienced support with insurance approvals
- Coordinated care if your treatment plan changes
- Access to KAP or other psychiatric services if Spravato® isn't the right fit
Insurance & coverage
Covered by Most Major Oregon Insurers
Spravato® is in-network with most major insurers, and our team handles the prior authorization paperwork for you — one of the biggest practical advantages of getting Spravato® through an experienced clinic.
Ketamine vs. Spravato®
Spravato® vs. Ketamine Therapy
| Spravato® (Esketamine) | Ketamine Therapy (KAP) | |
|---|---|---|
| FDA approved | Yes, for treatment-resistant depression | Used off-label |
| Administration | Nasal spray, self-administered under supervision | IV/IM, clinician-administered |
| Insurance | Covered by most major insurers | Often out-of-network; we provide reimbursement docs |
| Setting | In-office, ~2 hr monitoring (REMS) | In-office, structured KAP with LCSW |
| Best for | TRD patients who want an FDA-approved, covered option | Patients wanting therapy-integrated treatment for depression, anxiety, PTSD, trauma |
Your Care Team
CEO & Founder · Emergency Medicine background · Master's in Psychopharmacology · leads the medical side of the Ketamine program
Board-Certified Family Physician · 35+ years in medicine and psychiatry
Frequently Asked Questions
What is Spravato® and how is it different from traditional antidepressants?
Spravato® is an FDA-approved nasal spray containing esketamine, a derivative of ketamine, used for treatment-resistant depression. Unlike traditional antidepressants that primarily target serotonin, Spravato® works on the brain's glutamate system to help restore neural connections and may provide faster symptom relief for some patients.
Who is a good candidate for Spravato® treatment?
Spravato® is typically recommended for adults with major depressive disorder who have not responded adequately to at least two antidepressant medications. A comprehensive evaluation at Lonerock Clinic helps determine whether Spravato® is appropriate based on your diagnosis, medical history, and previous treatment response.
How does Spravato® fit into an overall depression treatment plan?
Spravato® is most effective when used as part of a comprehensive care plan. It is often combined with ongoing medication management, psychotherapy, and lifestyle support. At Lonerock Clinic, treatment is coordinated to ensure Spravato® aligns with your broader mental health goals and long-term stability.
What happens during a Spravato® treatment session?
During a Spravato® session, the nasal spray is self-administered under medical supervision in a controlled clinical setting. Patients remain in the clinic for observation for approximately two hours so providers can monitor blood pressure, side effects, and overall response before discharge.
Are there side effects with Spravato®?
Common side effects include dizziness, nausea, mild increases in blood pressure, and temporary dissociation. These effects typically resolve within a few hours after treatment. Because Spravato® is administered under medical supervision, patients are closely monitored to ensure safety and comfort.
Is Spravato® covered by insurance?
Yes — Spravato® is FDA-approved and in-network with most major Oregon insurers. Our team handles prior authorization and benefit verification for you, which is one of the biggest advantages of getting Spravato® through an experienced clinic.
How is Spravato® different from ketamine therapy?
Spravato® (esketamine) is an FDA-approved nasal spray you self-administer under supervision; IV/IM ketamine is administered by a clinician and used off-label. Spravato® is typically insurance-covered and REMS-regulated; ketamine therapy is often out-of-network but allows therapy-integrated (KAP) treatment. Many patients are candidates for one or the other after evaluation.
Considering a referral? Our team can guide you and your prescriber through the process. Call (833) 646-3633.
References
Educational references only and not a substitute for individualized medical advice.
Find out if Spravato® is covered for you.
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