Treatment-Resistant Depression care at Lonerock Clinic in Eugene, Oregon

Conditions We Treat

Treatment-Resistant Depression Treatment in Eugene, Oregon

If you've tried antidepressants or therapy without enough relief, you don't have to keep trying the same thing. Lonerock specializes in treatment-resistant depression, combining research-driven psychiatric care, advanced medication strategies, Ketamine-Assisted Psychotherapy (KAP), and Spravato® (esketamine) to create a personalized treatment plan.

Medically reviewed by Camille Pincock, MS · Last reviewed June 2026

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PRATI- & Polaris-trained
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LCSW-led KAP
Ketamine + Spravato®
Insurance accepted
11,000+ patients served

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For many people, traditional antidepressants take weeks to work — or may not provide enough relief at all. At Lonerock Clinic, we offer advanced treatments like Ketamine Therapy and Spravato® (esketamine) that target depression in a different way. These therapies act on the brain's glutamate system to create new neural connections, often providing faster and more effective symptom relief for those struggling with treatment-resistant depression.

Our experienced providers take a personalized, integrative approach to psychiatric care, combining innovative treatments with therapy, personalized medication management, and whole-person support that recognizes the connection between mental and physical health. We focus on restoring balance — mentally, emotionally, and physically — so you can start feeling like yourself again.

Understanding your care

How Ketamine and Spravato® Work

Unlike traditional antidepressants that focus on serotonin, Ketamine and Spravato® (esketamine) act on a different neurotransmitter system, glutamate, to help the brain form new neural pathways. This process can rapidly improve mood, energy, and clarity — often within hours or days rather than weeks.

Rapid Relief of Symptoms

Many patients report feeling improvement in mood, motivation, and outlook after just a few sessions, offering hope where other treatments have failed.

Restores Brain Connectivity

These therapies help the brain rebuild and strengthen neural connections, supporting long-term emotional stability and resilience.

Complements Other Treatments

Ketamine and Spravato® are integrated into a comprehensive psychiatric treatment plan that may also include medication management, psychotherapy, and whole-person support.

What Is Treatment-Resistant Depression?

Treatment-resistant depression generally refers to depression that hasn't improved after trying at least two appropriate antidepressant medications. It doesn't mean your depression is untreatable—it simply means a different approach may be needed.

Coordinated care

Collaborative Care for Better Mental Health

We believe that integrated, team-based care is essential for effective mental health treatment. We work closely with your primary care physician, therapists, and other healthcare providers to ensure a coordinated approach tailored to your needs.

Integrated Treatment Plans

Our team communicates openly with your existing providers to develop a medication and therapy plan that aligns with your overall healthcare goals, ensuring consistency and safety.

Open Referrals Welcome

You don't need to be a Lonerock primary care patient to receive our mental health services. We accept referrals from any physician, making it easy to access specialized care.

Personalized Support

Every patient receives care that is individualized to their condition, lifestyle, and preferences, helping improve outcomes and maintain long-term mental wellness.

Your Care Team

Camille Pincock
CEO & Founder · Emergency Medicine background · Master's in Psychopharmacology · leads the medical side of the Ketamine program
Cedar Sharpe, LCSW
25+ years in mental health · Ketamine-Assisted Psychotherapy & psychedelic integration

Meet the full care team

Related care

Getting started

How It Works

1
Book Your Free Consultation
Call (833) 646-3633 or book online — often same-day or next-day.
2
Comprehensive Evaluation
A full psychiatric assessment so your plan fits your history, not a template.
3
Your Personalized Plan
Medication management, therapy, and interventional options as appropriate — with ongoing follow-up.

Ketamine vs. Spravato® vs. TMS: How to Choose

If you're comparing options for depression that hasn't fully responded to medication, three come up most often. Here's an honest look — including when each tends to fit best.

Ketamine therapy (KAP)
Fast-acting; works on the brain's glutamate system. Best when you want rapid relief plus therapy-integrated care that addresses the root, not just symptoms. Often out-of-network, but we provide reimbursement documentation.
Spravato® (esketamine)
An FDA-approved nasal spray for treatment-resistant depression, covered by most major insurers and delivered under monitoring. Best when you want an FDA-approved, insurance-friendly glutamate-based option.
TMS (transcranial magnetic stimulation)
A medication-free, FDA-cleared treatment using magnetic pulses, typically over several weeks. Best when you prefer a non-drug approach and longer-lasting results over rapid relief. Lonerock doesn't offer TMS in-house, but we'll tell you honestly if it's the better fit and help you find it.

The point isn't to push one treatment — it's to figure out the right path for you. That's what your evaluation at Lonerock is for.

Frequently Asked Questions

What are the most effective treatments for depression?

The most effective depression treatment depends on the individual. At Lonerock Clinic, care may include medication management, advanced treatments such as ketamine therapy or Spravato®, lifestyle interventions, and psychotherapy support when appropriate. Treatment plans are personalized based on symptom severity, medical history, and previous treatment response to ensure comprehensive, whole-person care.

How do I know if I need professional treatment for depression?

You may benefit from professional depression treatment if symptoms such as persistent sadness, loss of interest, low energy, sleep changes, or difficulty concentrating last more than two weeks or interfere with daily functioning. A clinical evaluation helps determine the severity of symptoms and the most appropriate level of care.

How quickly does depression treatment start working?

Traditional antidepressants may take several weeks to reach full effectiveness. Some advanced treatments, including ketamine-based therapies, may provide faster symptom relief for certain individuals. Response time varies, and consistent follow-up allows your provider to adjust treatment for optimal results.

What is the difference between ketamine therapy and Spravato®?

Ketamine therapy typically involves IV administration of ketamine, while Spravato® is an FDA-approved nasal spray containing esketamine. Both target the brain's glutamate system and are often used for treatment-resistant depression. Your provider will determine which option is most appropriate based on your diagnosis and treatment history.

Is depression treatment safe?

Yes, depression treatment is safe when guided by qualified medical professionals. At Lonerock Clinic, treatment plans are carefully evaluated, monitored, and adjusted as needed to support both effectiveness and patient safety throughout the recovery process.